Enlivex Announces a new publication “Apoptotic cell therapy for cytokine storm associated with acute severe sepsis” in Cell Death & Disease, a Nature Research Journal
- Data show a 90% decrease in mortality with AllocetraTM treatment in a murine cecal ligation and puncture severe sepsis model
Nes Ziona, Israel, July 20, 2020 (GLOBE NEWSWIRE) -- Enlivex Therapeutics Ltd. (Nasdaq: ENLV), a clinical-stage immunotherapy company, today announced the publication of “Apoptotic cell therapy for cytokine storm associated with acute severe sepsis” in Cell Death & Disease, a Nature Research Journal. The published studies were conducted in collaboration with researchers at the Rheumatology and Rare Disease Research Center, The Whohl Institute for Translational Medicine, and the Hadassah-Hebrew University Medical Center.
Preclinical data from the studies demonstrate the ability of AllocetraTM to broadly resolve cytokine storm-associated organ failure and reduce mortality by 90% in a murine cecal ligation and puncture (CLP) animal model of severe sepsis. The CLP model has been proposed to more closely replicate the nature and course of clinical sepsis, as compared to other models. Highlights from the manuscript (www.nature.com/articles/s41419-020-02748-8) include:
- In the CLP model, treatment with AllocetraTM in combination with antibiotics and fluids decreased mortality by 90% when compared to treatment with antibiotics and fluids alone.
- AllocetraTM-induced survival benefits in CLP mice were both dose dependent and statistically significant.
- CLP-induced sepsis led to widespread organ failure including in the lungs, heart, liver, and kidneys, all of which were resolved with AllocetraTM treatment.
- CLP-mice saw broad elevation of cytokines and chemokines across multiple immune modulation subsystems that decreased with AllocetraTM treatment.
- A positive effect by AllocetraTM treatment was shown for the first time both in aerobic and anaerobic metabolism of the immune system leading to significant improvement in both mitochondrial respiration and glycolytic reserve.
“We are very pleased with the peer-reviewed publication of these compelling preclinical data, as we believe that they provide important validation for the beneficial and robust effects of AllocetraTM across a broad range of organ systems,” said Prof. Dror Mevorach, M.D., Chief Scientific and Medical Officer of Enlivex and lead author of the study. “Importantly, the data are consistent with our previously reported Phase Ib clinical trial results, demonstrating improved survival and early resolution of cytokine storms in severe sepsis patients treated with AllocetraTM. Taken together, these clinical and preclinical studies highlight the potential of AllocetraTM to treat not only sepsis, but also similar pathologies associated with cytokine storms and multi-system organ failure, including those associated with severe cases of COVID-19.”
Enlivex is a clinical stage immunotherapy company, developing an allogeneic drug pipeline for immune system rebalancing. Immune system rebalancing is critical for the treatment of life-threatening immune and inflammatory conditions which involve hyper-expression of cytokines (Cytokine Release Syndrome) and for which there are no approved treatments (unmet medical needs), as well as solid tumors immune-checkpoint rebalancing. For more information, visit http://www.enlivex.com.
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Shachar Shlosberger, CFO
Enlivex Therapeutics, Ltd.
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